The weirdest damn game that I have ever played is Seventh Cross Evolution for the Dreamcast. I double teamed it with a friend for over 100 hours only to be killed by the people you are saving because you don't look human.
Mario and Luigi Superstar Saga?
Given what EA has done to the 'Dungeon Keeper' franchise lately I think gamers needed to be reminded of how good the original (& sequel) was. Please VGV 'Dungeon Keeper'